Spatiotemporal Modeling Quantifies Cellular Contributions to Uptake of Aspergillus fumigatus in the Human Lung

Saffer B C, Timme S, Ortiz SC, Bertuzzi M, Figge MT (2024). Spatiotemporal Modeling Quantifies Cellular Contributions to Uptake of Aspergillus fumigatus in the Human Lung. Communications Biology.

This paper simulates a geometric reconstruction of the alveolar space to quantify how much each resident immune cell population contributes to clearing inhaled Aspergillus fumigatus conidia, decomposing cell-level uptake dynamics to explain the aggregate, tissue-level course of early infection in the lung.